Total Flavone Content of Cydonia oblonga Miller Inhibits Proliferation and Migration of Renal Carcinoma Cells by Inhibiting the S1PR2/FAK Pathway

Cydonia oblonga Miller (C. oblonga) is known for its beneficial properties health since ancient times. C. has also been shown to possess antihemolytic, antidiabetic, and antilipoperoxidation, as well lipid-lowering properties. Modern research that antitumor effects. However, studies have not reported whether main compounds inhibit renal cell carcinoma (RCC) development progression. We found the inhibitory effect of total flavone (TFCOM) in RCC cells through vitro screening tests. The molecular mechanism this still unknown. Therefore, docking combined with network pharmacological methods was used order clarify mechanisms TFCOM anticancer showed potent effects on proliferation migration 786-O Renca cells. Hoechst 33342 staining test results indicated TFCOM’s growth inhibition may be mediated apoptosis. It significantly influence S1PR2/FAK, WNT/β-catenin, PI3K/AKT/mTOR signaling pathways can regulate a series cellular activities participate processes proliferation, migration, conclude activity against kidney cancer. induce apoptosis signal pathways. might potential drug further developed human cancer therapy. In recent years, many synthetic drugs disadvantages high price side Thus, from natural resources application value. Our suggest TFCOM, product, multiple target effects, it act proteins receptors such FAK S1PR2, thereby affecting activation downstream inhibiting occurrence